FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 2-amino-9-aroyl-8-hydroxy-6-(2-hydroxyphenyl)-1-thia-3,6-diazaspiro[4.4]nona-2,8-dien-4,7-dione , which can be used as initial products for synthesis of novel heterocyclic systems and in pharmacology. 2-amino-9-aroyl-8-hydroxy-6-(2-hydroxyphenyl)-1-thia-3,6-diazaspiro[4.4]nona-2,8-diene-4,7-diones represented by formula (II), where Ar=Ph, R=Cl (a); Ar=C6H4Cl-4, R=H (b), Ar=C6H4Me-4, R=H (c) is obtained by reacting 3-aroylpyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones of formula (I) with thiourea in a medium of an inert aprotic solvent, followed by separation of desired products.
EFFECT: synthesis of 2-amino-9-aroyl-8-hydroxy-6-(2-hydroxyphenyl)-1-thia-3,6-diazaspiro[4.4]nona-2,8-diene-4,7-diones, having antimicrobial activity.
1 cl, 1 tbl, 4 ex
а - a
в - c
| Title |
Year |
Author |
Number |
| METHOD FOR PREPARATION OF 9-AROYL-8-HYDROXY-6-(2-HYDROXYPHENYL)-2-PHENYL-1-THIA-3,6-DIAZASPIRO[4,4]NON-2,8-DIENE-4,7-DIONES |
2016 |
- Stepanova Ekaterina Evgenevna
- Maslivets Andrej Nikolaevich
- Kobelev Aleksandr Ivanovich
- Balandina Svetlana Yurevna
|
RU2631432C1 |
| PROCESS FOR THE PREPARATION OF 4-AROYL-3-HYDROXY-1- (2-HYDROXYPHENYL) -8-THIOXO-1,7-DIAZASPIRO [4,4] NON-3-ENE-2,6-DIONES |
2016 |
- Stepanova Ekaterina Evgenevna
- Maslivets Andrej Nikolaevich
- Kobelev Aleksandr Ivanovich
- Balandina Svetlana Yurevna
|
RU2627276C1 |
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- Aleksandrova Galina Arsent'Evna
|
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2021 |
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|
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2022 |
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2023 |
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|
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2011 |
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|
RU2467010C1 |
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2021 |
- Maslivets Andrej Nikolaevich
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- Babikova Natalya Vladimirovna
|
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2023 |
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