FIELD: pharmacology.
SUBSTANCE: invention relates to a method for preparation of 9-aroyl-8-hydroxy-6-(2-hydroxyphenyl)-2-phenyl-1-thia-3,6-diazaspiro[4.4]non-2,8-diene-4,7-diones represented by general formula II (a-c), where Ar = C6H4Br-4 (a), C6H4Cl-4 (b), Ph (c), X = H (a, b), Cl (c). A method for preparation of 9-aroyl-8-hydroxy-6-(2-hydroxyphenyl)-2-phenyl-1-thia-3,6-diazaspiro[4.4]non-2,8-diene-4,7-diones is implemented by interaction of 3-aroylpyrrolo[2,1-c][1,4] benzoxazine-1,2,4-triones with thiobenzamide in an inert aprotic solvent, followed by isolation of the desired products. Dry toluene is used as the solvent.
EFFECT: preparation of these compounds, which can be used as raw products for synthesis of new heterocyclic systems and in pharmacology.
2 cl, 1 tbl, 4 ex
| Title |
Year |
Author |
Number |
| METHOD OF PRODUCING 2-AMINO-9-AROYL-8-HYDROXY-6-(2-HYDROXYPHENYL)-1-THIA-3,6-DIAZASPIRO[4.4]NONA-2,8-DIENE-4,7-DIONE |
2019 |
- Maslivets Andrej Nikolaevich
- Kobelev Aleksandr Ivanovich
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- Balandina Svetlana Yurevna
|
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2022 |
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|
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| PROCESS FOR THE PREPARATION OF 4-AROYL-3-HYDROXY-1- (2-HYDROXYPHENYL) -8-THIOXO-1,7-DIAZASPIRO [4,4] NON-3-ENE-2,6-DIONES |
2016 |
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|
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2023 |
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|
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2022 |
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|
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2008 |
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|
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2021 |
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|
RU2767558C1 |
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2022 |
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|
RU2783241C1 |
| (Z)-9-AROYL-8-HYDROXY-6-(2-HYDROXYPHENYL)-2-(((Z)-2-OXOINDOLIN-3-YLIDENE)HYDRAZONO)-1-THIA-3,6-DIAZASPIRO[4.4 ]NON-8-EN-4,7-DIONES WITH ANTIMICROBIAL ACTIVITY |
2021 |
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|
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2021 |
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|
RU2767555C1 |
