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2 631 432

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IPC

C07D513/10(2006-01-01)

A61P31/04(2006-01-01)

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Application

2016127941, 2016-07-11

(24)

Start date

2016-07-11

(22)

Actual filing date

2016-07-11

(45)

Published

2017-09-22

(72)

Inventor

Stepanova Ekaterina EvgenevnaMaslivets Andrej NikolaevichKobelev Aleksandr IvanovichBalandina Svetlana Yurevna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD FOR PREPARATION OF 9-AROYL-8-HYDROXY-6-(2-HYDROXYPHENYL)-2-PHENYL-1-THIA-3,6-DIAZASPIRO[4,4]NON-2,8-DIENE-4,7-DIONES Russian patent published in 2017 - IPC C07D513/10 A61P31/04

Abstract RU 2631432 C1

FIELD: pharmacology.

SUBSTANCE: invention relates to a method for preparation of 9-aroyl-8-hydroxy-6-(2-hydroxyphenyl)-2-phenyl-1-thia-3,6-diazaspiro[4.4]non-2,8-diene-4,7-diones represented by general formula II (a-c), where Ar = C₆H₄Br-4 (a), C₆H₄Cl-4 (b), Ph (c), X = H (a, b), Cl (c). A method for preparation of 9-aroyl-8-hydroxy-6-(2-hydroxyphenyl)-2-phenyl-1-thia-3,6-diazaspiro[4.4]non-2,8-diene-4,7-diones is implemented by interaction of 3-aroylpyrrolo[2,1-c][1,4] benzoxazine-1,2,4-triones with thiobenzamide in an inert aprotic solvent, followed by isolation of the desired products. Dry toluene is used as the solvent.

EFFECT: preparation of these compounds, which can be used as raw products for synthesis of new heterocyclic systems and in pharmacology.

2 cl, 1 tbl, 4 ex

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RU 2 631 432 C1

Authors

Stepanova Ekaterina Evgenevna

Maslivets Andrej Nikolaevich

Kobelev Aleksandr Ivanovich

Balandina Svetlana Yurevna

Dates

2017-09-22—Published

2016-07-11—Filed