FIELD: medicine.
SUBSTANCE: invention relates to laboratory diagnostics and can be used to diagnose intolerance to acrylic structural materials of removable lamellar dentures in elderly and senile patients, namely from 60 to 89 years, in the absence of metal inclusions in the oral cavity in the form dentures, crowns, and inlays. Essence: by cytological examination of the buccal epithelium of the oral cavity, apoptotic and reparative indices are determined, physicochemical studies of the oral fluid are performed, as a result of which the quantitative values of pH, total protein and leukocytes are determined. In addition, the levels of matrix metalloproteinases of type 8 and type 9 (MMP-8, MMP-9) are determined in the oral fluid, the presence and level of immunoglobulin E (IgE) are also determined. With quantitative values of the apoptotic index of buccal epithelium of 1.12 and higher, reparative index of buccal epithelium of 0.67 and lower, with quantitative values in the oral fluid of pH 6 and lower, total protein of 0.5 and higher, leukocytes of 65 and higher, with a quantitative value levels of MMP-8 1,984–23,982 pg/ml, MMP-9 1,142–5,776 pg/ml, with an IgE content of 1.50–32.50, in total, the intolerance of acrylic structural materials of removable lamellar dentures is diagnosed.
EFFECT: increased reliability of diagnosing intolerance to acrylic structural materials of removable lamellar dentures in elderly and senile patients, increased efficiency of orthopedic treatment of patients with partial and complete loss of teeth with intolerance to acrylic structural materials of removable lamellar dentures; the possibility to prevent intolerance to acrylic structural materials of removable lamellar dentures; the possibility of using to control the results of treatment of intolerance to acrylic structural materials of prostheses in patients with removable laminar prostheses; expansion of the arsenal of tools for diagnosing intolerance to acrylic structural materials of removable lamellar dentures in elderly and senile patients.
1 cl, 2 ex
