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2 794 798

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(51)

IPC

A61K31/00(2006-01-01)

C12N15/00(2006-01-01)

B82Y40/00(2011-01-01)

A61K31/70(2006-01-01)

A61K31/7028(2006-01-01)

A61K31/704(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2021133851, 2021-11-22

(24)

Start date

2021-11-22

(22)

Actual filing date

2021-11-22

(45)

Published

2023-04-25

(72)

Inventor

Ipatova Olga MikhajlovnaTikhonova Elena GeorgievnaSanzhakov Maksim AleksandrovichTereshkina Yuliya AleksandrovnaKhudoklinova Yuliya YurevnaKostryukova Lyubov ViktorovnaTorkhovskaya Tatyana IvanovnaRadko Sergej PavlovichKhmeleva Svetlana AleksandrovnaOrlova Nadezhda Alekseevna

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennostyu

PHARMACEUTICAL COMPOSITION CONTAINING DOXORUBICIN AS PART OF PHOSPHOLIPID NANOPARTICLES USING SELECTIVE DNA APTAMER MOLECULES FOR TARGETED TRANSPORT TO TUMOR CELLS Russian patent published in 2023 - IPC A61K31/00 C12N15/00 B82Y40/00 A61K31/70 A61K31/7028 A61K31/704 A61P35/00

Abstract RU 2794798 C1

FIELD: biotechnology.

SUBSTANCE: group of inventions is described that contains a pharmaceutical composition of doxorubicin included in phospholipid nanoparticles with AS1411 aptamer in the form of a conjugate with DSPE-PEG2000-Mal, for targeted delivery of a cytostatic agent to a tumor, and a method for producing the composition. In one of the embodiments of the invention, the pharmaceutical composition contains phospholipids, doxorubin and AS1411 aptamer conjugate with DSPE-PEG₂₀₀₀ -Mal.

EFFECT: invention expands the arsenal of means for targeted delivery of a cytostatic agent to a tumor.

2 cl, 4 dwg, 2 tbl, 3 ex

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RU 2 794 798 C1

Authors

Ipatova Olga Mikhajlovna

Tikhonova Elena Georgievna

Sanzhakov Maksim Aleksandrovich

Tereshkina Yuliya Aleksandrovna

Khudoklinova Yuliya Yurevna

Kostryukova Lyubov Viktorovna

Torkhovskaya Tatyana Ivanovna

Radko Sergej Pavlovich

Khmeleva Svetlana Aleksandrovna

Orlova Nadezhda Alekseevna

Dates

2023-04-25—Published

2021-11-22—Filed