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RU

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2 747 485

(13)

C1

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IPC

A61K31/409(2006-01-01)

A61K47/30(2006-01-01)

A61K47/62(2017-01-01)

B82B1/00(2006-01-01)

B82Y5/00(2011-01-01)

(21) (22)

Application

2020116793, 2020-05-18

(24)

Start date

2020-05-18

(22)

Actual filing date

2020-05-18

(45)

Published

2021-05-05

(72)

Inventor

Prozorovskij Vladimir NikolaevichKostryukova Lyubov ViktorovnaKorotkevich Evgeniya IgorevnaTereshkina Yuliya AleksandrovnaTikhonova Elena GeorgievnaKhudoklinova Yuliya Yurevna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Institut Biomeditsinskoj Khimii Imeni V.N. Orekhovicha"

PHARMACEUTICAL COMPOSITION CONTAINING CHLORIN E6 IN PHOSPHOLIPID NANOPARTICLES USING SPECIFIC AND PENETRATING PEPTIDES AS TARGETED MOLECULES FOR TARGETED TRANSPORT Russian patent published in 2021 - IPC A61K31/409 A61K47/30 A61K47/62 B82B1/00 B82Y5/00 

Abstract RU 2747485 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to means of targeted delivery of drugs to target cells. Disclosed is a pharmaceutical composition of chlorin e6 in the form of phospholipid nanoparticles less than 40 nm in size for photodynamic therapy in the treatment of oncological diseases, including a specific peptide with an NGR motif and a penetrating peptide R7, which is heptaarginine, and a method for its preparation.

EFFECT: pharmaceutical composition has increased cell-permeability, high cytotoxic and photoinduced activities.

2 cl, 3 tbl, 4 ex, 3 dwg

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RU 2 747 485 C1

Authors

Prozorovskij Vladimir Nikolaevich

Kostryukova Lyubov Viktorovna

Korotkevich Evgeniya Igorevna

Tereshkina Yuliya Aleksandrovna

Tikhonova Elena Georgievna

Khudoklinova Yuliya Yurevna

Dates

2021-05-05—Published

2020-05-18—Filed

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