METHOD FOR CREATING BIOENGINEERED VASCULAR GRAFTS OF LARGE AND MEDIUM DIAMETERS Russian patent published in 2023 - IPC A61F2/06 A61F2/07 A61L27/52 A61L27/20 B05D1/36 

FIELD: biological engineering.

SUBSTANCE: method for creating bioengineered vascular grafts, including the layer-by-layer creation of a workpiece from an alginate-gelatin hydrogel with a concentration of sodium alginate 4% and gelatin 6% and a reference gelatin hydrogel with a gelatin concentration of 8%, followed by processing the workpiece with a 1% solution of calcium chloride, removing the reference gelatin hydrogel by depolymerizing it at 37°C, processing the preform with 5% sodium citrate solution, rolling it from the inside with glass rods or smooth tweezers until the required wall thickness, vessel diameter and smoothness of its surface are reached, and treatment with 2% alginate hydrogel to form the adventitial shell of the obtained vessel.

EFFECT: development of a simple, economical method for creating bioengineered vascular grafts of various diameters and configurations based on alginate hydrogel with the possibility of including vascular wall cells in the graft structure.

1 cl, 4 dwg, 1 ex