COMPRESSED AIR METERED-DOSE INHALER CONTAINING A BUFFERED PHARMACEUTICAL COMPOSITION Russian patent published in 2023 - IPC A61M15/00 A61K31/167 A61K31/40 A61K47/06 A61K47/10 A61P11/00 

FIELD: inhalers.

SUBSTANCE: group of inventions relates to a container for use in a compressed air metered-dose inhaler (pMDI) device, said container containing a composition containing at least a corticosteroid selected from budesonide and beclomethasone dipropionate, formoterol fumarate dihydrate, and a propellant selected from 1, 1-difluoroethane (HFA152a) or 1,3,3,3-tetrafluoropropene (HFO-1234ze), wherein said container is coated on the inside with a coating containing at least a fluorinated ethylene propylene (FEP) polymer, and a valve, wherein the valve is equipped with a sealing ring made of cycloolefin copolymer (COC), together with two o-rings made of polymer based on ethylene propylene diene monomer (EPDM), or the valve is equipped with two o-rings, both of which are made of chlorobutyl polymer, and also applies to the pMDI device.

EFFECT: group of inventions provides for reduction of the global warming potential (GWP) and stabilization with respect to calibration and maintenance of the apparent pH value of the composition.

12 cl, 2 tbl, 2 ex