METHOD OF OBTAINING TAPINAROF Russian patent published in 2023 - IPC C07C37/07 C07C39/21 C07C45/63 C07C49/697 C07C51/38 C07C59/84 C07C67/08 C07C69/738 A61K31/05 A61P17/00 

Abstract RU 2795144 C2

FIELD: chemistry.

SUBSTANCE: invention relates to variants of the method for obtaining the compounds of formula (I), which has several potentially useful biological reactions, including antibacterial, antioxidant, and anticancer activity, or a salt or solvate thereof, to processes for preparing intermediates, as well as to intermediates for preparing a compound of formula I. One embodiment of a process for preparing a compound of formula I involves aromatization compounds of formula (II)

, where X represents Cl, Br or I.

EFFECT: technical result is the development of a highly productive synthesis of the compound of formula I without any potential problems with toxicity.

28 cl, 2 dwg, 2 tbl, 7 ex

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RU 2 795 144 C2

Authors

Andrews Ian Paul

Calandra Nicholas

Davis Tyler Andrew

Sudini Ravinder Reddy

Dates

2023-04-28Published

2018-11-13Filed