FIELD: medicine.
SUBSTANCE: invention relates to pulmonology, and can be used to assess the development of an unfavorable course of chronic obstructive pulmonary disease (COPD). In a patient with a moderate course of the disease, an analysis of laboratory parameters pathogenetically significant in COPD is carried out, in which, on the first day after hospitalization for an exacerbation of moderate COPD, the post-broncholitic forced expiratory volume in the first second (FEV1), fibrinolytic activity of the blood is determined by the euglobulin method, immunological studies by determining cytokines in the bronchoalveolar fluid — interferon-gamma (IFNγ), interleukin-4 (IL-4) by enzyme immunoassay, the relative content of CD3+CD4+ cells by direct immunofluorescence and segmented neutrophils in peripheral blood, while the values of these indicators are entered into the equation to determine the Z index. Then the resulting Z value is entered into the formula for calculating the probability of death P=1/(1+e-Z)×100%, where e is the base of the natural logarithm, equal to 2.718. If the P value is greater than 44.8%, COPD death is predicted within 15 years, and if the value of the indicator is equal to or less than 44.8%, a favorable outcome is predicted.
EFFECT: invention provides increased sensitivity and specificity of survival prognosis in the early stages of COPD, mainly in patients with moderate bronchial obstruction (GOLD2) without concomitant diseases of the cardiovascular system and neurological disorders.
1 cl, 3 dwg, 8 tbl, 3 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD FOR PREDICTION OF INFECTIOUS COMPLICATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 2015 |
|
RU2595853C1 |
METHOD FOR EVALUATING THE UNFAVORABLE COURSE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ARTERIAL HYPERTENSION WHEN COMBINED | 2018 |
|
RU2711453C1 |
METHOD FOR PREDICTING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN PERSONS WORKING UNDER EXPOSURE TO INDUSTRIAL AEROSOLS | 2021 |
|
RU2774206C1 |
METHOD OF ASSESSING RISK OF PROGRESSION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 2022 |
|
RU2805829C1 |
METHOD FOR PREDICTING SURVIVAL IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 2021 |
|
RU2756025C1 |
METHOD FOR PREDICTION EFFICACY OF GLUCOCORTICOID THERAPY IN PATIENTS WITH AGGRAVATED CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 2011 |
|
RU2490645C2 |
METHOD FOR PREDICTING RECRUDESCENCE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN PATIENTS WITH INSOMNIA | 2018 |
|
RU2681272C1 |
METHOD FOR EARLY PREDICTION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE OF DISEASE PROGRESSION | 2020 |
|
RU2740071C1 |
METHOD OF PREDICTING THE DEVELOPMENT OF OCCUPATIONAL CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN PERSONS WORKING UNDER CONDITIONS OF EXPOSURE TO INDUSTRIAL AEROSOLS CONTAINING NANOPARTICLES WITH SILICON | 2023 |
|
RU2803246C1 |
METHOD OF PROGRESS FORECAST FOR CHRONIC OBSTRUCTIVE LUNG DISEASE | 2008 |
|
RU2370773C1 |
Authors
Dates
2023-05-02—Published
2021-11-26—Filed