PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII Russian patent published in 2023 - IPC C07K1/06 C07K5/06 C07K5/08 C07K5/12 A61K38/05 A61K38/06 A61K38/12 A61P31/04 

Abstract RU 2795374 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to compounds selected from 4-[(11S,14S,17S)-14-(4-aminobutyl)-11-(3-amino-3-oxo-propyl)-25-chloro-17-(1H-indole-3-ylmethyl)-16-methyl-12,15,18-trioxo-2-thia-4,10,13,16,19-pentaazatricyclo[19.4.0.03.8]pentacose-1(21),3,5,7,22,24-hexaen-22-yl]benzoic acid; 4-[(11S,14S,17S)-14-(4-aminobutyl)-11-(3-aminopropyl)-17-(1H-indol-3-ylmethyl)-16-methyl-12,15,18-trioxo-2-thia-4,10,13,16,19-pentaazatricyclo[19.4.0.03.8]pentacose-1(25),3(8),4,6,21,23-hexaen-22-yl]benzoic acids; 4-[(11S,14S,17S)-14-(4-aminobutyl)-11-(3-aminopropyl)-25-chloro-17-(1H-indol-3-ylmethyl)-16-methyl-12.15,18-trioxo-2-thia-4,7,10,13,16,19-hexaazatricyclo[19.4.0.03.8]pentacose-1(21),3,5,7,22,24-hexaen-22-yl]benzoic acid; 2-chloro-4-[rac-(11S,14S,17S)-14-(4-aminobutyl)-11-(3-aminopropyl)-25-chloro-17-(1H-indol-3-ylmethyl)-16-methyl-12,15,18-trioxo-2-thia-4,7,10,13,16,19-hexaazatricyclo[19.4.0.03.8]pentacose-1(21),3,5,7,22, 24-hexaen-22-yl]benzoic acid; 4-[(11S,14S,17S)-14-(4-aminobutyl)-11-(3-aminopropyl)-25-chloro-17-(1H-indol-3-ylmethyl)-16-methyl-12.15,18-trioxo-2-thia-4,7,10,13,16,19-hexaazatricyclo[19.4.0.03.8]pentacose-1(21),3,5,7,22,24-hexaen-22-yl]-2-fluorobenzoic acid; 4-[(11S,14S,17S)-14-(4-aminobutyl)-11-(3-aminopropyl)-25-fluoro-17-(1H-indol-3-ylmethyl)-16-methyl-12.15,18-trioxo-2-thia-4,10,13,16,19-pentaazatricyclo[19.4.0.03.8]pentacose-1(25),3(8),4,6,21,23-hexaene-22-yl]benzoic acid; 4-[(11S,14S,17S)-14-(4-aminobutyl)-11-(3-aminopropyl)-25-chloro-17-(1H-indol-3-ylmethyl)-16-methyl-12,15,18-trioxo-2-thia-4,10,13,16,19-pentaazatricyclo[19.4.0.03.8]pentacose-1(25),3(8),4,6,21,23-hexaene-22-yl]-2-methylsulfonyl-benzoic acid; 4-[(11S,14S,17S)-14-(4-amino-3,3-difluoro-butyl)-11-(3-aminopropyl)-25-chloro-17-(1H-indol-3-ylmethyl)-16-methyl-12,15,18-trioxo-2-thia-4,10,13,16,19-pentaazatricyclo[19.4.0.03.8]pentacose-1(21),3,5,7,22, 24-hexaen-22-yl]benzoic acid, etc., as well as their pharmaceutically acceptable salts, which are capable of inhibiting the growth of Acinetobacter baumannii bacteria.

EFFECT: invention also relates to a pharmaceutical composition containing the said compounds, a method for inhibiting the growth of Acinetobacter baumannii bacteria, and the use of the compounds to inhibit the growth of Acinetobacter baumannii bacteria or to obtain a drug for inhibiting the growth of Acinetobacter baumannii bacteria.

14 cl, 1 tbl, 23 ex

Similar patents RU2795374C2

Title Year Author Number
PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII 2016
  • Alanin Aleksander
  • Bene Zhyulen
  • Blajger Konrad
  • Fashing Bernard
  • Khilpert Khans
  • Khu Tajshan
  • Makdonald Duajt
  • Dzhekson Stiven
  • Kolchevski Sabine
  • Kroll Karsten
  • Shojblin Adrian
  • Shen Khun
  • Shtoll Teodor
  • Tomas Khelmut
  • Vakhkhab Amal
  • Tsampaloni Klaudia
RU2729609C2
AMIDE COMPOUND 2009
  • Nozava Ehjsuke
  • Ibuka Riotaro
  • Ikegai Kazukhiro
  • Matsuura Kejsuke
  • Zenkokh Tatsuja
  • Seo Rjusi
  • Vatanuki Susumu
  • Kagejama Mitikhito
RU2479576C9
SULFONAMIDE-CONTAINING BINDING SYSTEMS FOR MEDICINAL CONJUGATES 2014
  • Winters Geoffrey C.
  • Mandel Alexander L.
  • Bourque Elyse Marie Josee
  • Rich James R.
  • Hsieh Tom Han Hsiao
RU2729194C2
TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES AND METHODS FOR USING THEM FOR PSMA INHIBITION 2009
  • Babich Dzhon U.
  • Tsimmerman. Krejg
  • Dzhojal Dzhon
  • Mareska Kevin P.
  • Lu Genliang
  • Khil'Er Shon
RU2532912C2
STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES 2015
  • Dushin Russell George
  • Strop Pavel
  • Dorywalska Magdalena Grazyna
  • Moine Ludivine
RU2680238C2
NEW INDOLIZINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 2013
  • Le-Digare Terri
  • Kasara Patrik
  • Stark Zherom-Benua
  • Anlen Zhan-Mishel
  • Dejvidson Dzhejms Eduard Pol
  • Marri Dzhejms Bruk
  • Grem Kristofer Dzhon
  • Chen Itszen
  • Zhenes Olive
  • Khikman Dzhon
  • Depil Stefan
  • Le-Tiran Arno
  • Niergesh Miklosh
  • De-Nantej Gijom
RU2646223C2
AMIDE DERIVATIVES OF 2,3,4,5-TETRAHYDROBENZO {f}-{1,4} OXAZEPINE-5-CARBOXYLIC ACID AS INHIBITOR OF Y-SECRETASE FOR TREATMENT OF ALZHEIMER'S DISEASE 2004
  • Gallej Guido
  • Gudnou Dzhr Robert Alan
  • Peters Jens Uve
RU2332408C2
BRUTON'S TYROSINE KINASE INHIBITORS 2014
  • Lopez-Tapia Fransisko Khaver
  • So Sun-Sau
  • Tsyao Tsi
  • Dominik Romir
RU2653504C2
TECHNETIUM AND RHENIUM COMPLEXES WITH BIS(HETEROARYLS) AND METHODS FOR USING THEM 2009
  • Babich Dzhon U.
  • Tsimmerman Krejg
  • Dzhojal Dzhon
  • Mareska Kevin P.
  • Lu Genliang
  • Van Tszjan'-Chehn
  • Khil'Er Shon
  • Markis Dzhon
RU2539584C2
PHENYLPROPANAMIDE DERIVATIVE, A METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF 2017
  • Li, Sin
  • Van, Bin
  • Tsyan, Ventszyan
  • Chen, Yan
  • Khe, Fen
  • Tao, Vejkan
RU2738207C2

RU 2 795 374 C2

Authors

Blajger, Konrad

Cheang, Daniella

Di Dzhordzho, Patrik

Khu, Tajshan

Jenni, Kristian

Mattej, Patritsio

Shmits, Petra

Shtoll, Teodor

Dates

2023-05-03Published

2019-04-23Filed