SULFONAMIDE-CONTAINING BINDING SYSTEMS FOR MEDICINAL CONJUGATES Russian patent published in 2020 - IPC A61K38/08 A61K47/68 A61P35/00 

FIELD: pharmaceuticals; medicine.

SUBSTANCE: group of inventions relates to a conjugate having structure (I): [(P)-(L)]_m-(T) (I), where: (L) is a linker; (T) is an antibody or antibody fragment which specifically binds to an antigen, present on tumor cell; m is integer from 1 to 10 and (P) has structure (VI) or (XId):

,

and (L)-(T) has structure (III):

,

where each AA independently represents an amino acid; x is integer from 0 to 25 and (L') is optionally a linker (L) residue. Group of inventions also relates to a pharmaceutical composition, containing said conjugate, to using a conjugate for preparing a drug for treating cancer in a mammal and a method of treating cancer in a mammal, comprising administering an effective amount of the conjugate.

EFFECT: disclosed are sulphonamide-containing binding systems for drug conjugates.

27 cl, 17 dwg, 3 tbl, 33 ex