METHOD FOR PRODUCTION OF SILICON NANOPARTICLES FOR CORONAVIRUS INFECTION INACTIVATION Russian patent published in 2023 - IPC C01B33/21 C01B33/37 C25F3/12 B82B3/00 A61L2/18 

FIELD: nanoparticles.

SUBSTANCE: proposed method for production of aqueous suspensions of silicon nanoparticles includes etching of crystalline silicon wafers of p-type with (100) surface orientation and resistivity of 1 to 50 mΩ * cm in a solution of hydrofluoric acid with volume concentration of 40-50% and ethanol in a ratio of 1:1 to 1:5 by volume, respectively, for a period of time from 10 to 60 min with a current density of 20 to 60 mA/cm², with further mechanical grinding of the resulting mesoporous layers with a thickness of 10 to 100 μm, pore diameter of 2 to 10 nm and porosity from 50 to 80%. Separate resulting mesoporous silicon films from the substrate, wash in distilled water, dry in air at room temperature and subject to mechanical grinding in distilled water by grinding in a planetary ball mill to obtain aqueous suspension of silicon nanoparticles. Then subject the resulting suspension to centrifugation with centrifugal accelerations from 1000 to 2000 of gravity acceleration for period from 10 to 20 min to precipitate large silicon nanoparticles, which are then removed from the suspension. Subsequently use the supernatant fraction of nanoparticle suspension, which is subjected to dialysis for 24 hours in dialysis bags with a pore size of 40 kDa to remove the smallest nanoparticles and solutes.

EFFECT: as a result, a stable aqueous suspension of silicon nanoparticles with average transverse dimensions of about 100 nm is formed, which are aggregates of silicon nanocrystals of 10–20 nm in size, which have high stability for several weeks, high efficiency of coronavirus inactivation and low cytotoxicity.

1 cl, 2 dwg, 1 tbl, 2 ex