METHOD FOR PREPARING WATER SUSPENSION OF BIOCOMPATIBLE POROUS SILICON PARTICLE Russian patent published in 2014 - IPC A61K49/00 A61K33/00 A61K9/10 A61J3/00 B82B1/00 B82Y5/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a method for preparing a water suspension of silicon nanocrystalline particles for biomedical applications. The declared method is characterised by the fact that a porous silicon film of the thickness of 1 to 100 mcm and the porosity of 50 to 80% is formed on the surface of silicon plates. The film is formed by electrochemical etching in a solution containing 40-50% aqueous solution of fluoric acid and alcohol in ratio 1:1 to 1:5 for a period of time of 10 to 60 minutes at specific current 20 to 60 mA/cm². The prepared silicon plates coated with a porous silicon layer is washed in distilled water, dried and placed in a container with distilled water. Then, they are exposed to ultrasound for more than 10 minutes at the intensity of the silicon plate exposure in water of 100 Wt/cm² at frequency 23 kHz. This provides forming the stable suspension in distilled water from nanoparticles of the lateral dimension of 10 to 500 nm.

EFFECT: invention provides preparing the biocompaticle suspension of silicon nanoparticles that penetrate into living cells preserving its useful biological properties and luminescence.

4 dwg, 1 ex