PHOSPHORUS(N)AMIDATEACETAL AND PHOSPH(OH)ATACETAL COMPOUNDS Russian patent published in 2023 - IPC C07F9/6561 C07H19/10 A61K31/7072 A61K31/7068 A61K31/675 A61P1/16 

FIELD: organic chemistry; pharmacology.

SUBSTANCE: group of inventions relates to the preparation of nucleos(t)ide analogs targeted at the liver. A compound of formula IVa or a pharmaceutically acceptable salt of the said compound, where R¹ and R² are independently selected from the group consisting of C₁-C₆ alkyl; or alternatively R¹ and R² together with the atoms to which they are attached form a four to ten-membered heterocycle with two oxygen atoms as heteroatoms, optionally substituted with C₁-C₆ alkyl; each R³ is independently selected from the group consisting of hydrogen and C₁-C₆ alkyl, optionally substituted with phenyl; each R⁶ is independently C₁-C₆ alkyl; m is 0, 1, 2 or 3; n is 1 or 2; and X is O (oxygen) or NH are revealed. In addition, pharmaceutical compositions for the treatment of HIV and viral liver infection, methods for treating HIV and viral liver infection, as well as a method for inhibiting viral replication in the hepatocyte are disclosed. In addition, the use of the disclosed compound for the preparation of a medicament for the treatment of a viral infection of the liver, as well as the use of the compound for the treatment of a viral infection of the liver, is described.

EFFECT: group of inventions provides effective treatment of viral infection of the liver and HIV by interfering with molecular pathways in the liver.

49 cl, 3 tbl, 62 ex

(IVa)