CYCLIC DEOXYRIBONUCLEOTIDE COMPOUNDS Russian patent published in 2025 - IPC C07H19/11 A61K31/7072 A61P1/16 A61P35/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to a compound of formula I or II or a pharmaceutically acceptable salt thereof, which can be used to treat a disease, disorder or condition which is treatable with a thymidylate synthase inhibitor. In Formula IR¹ is selected from a group consisting of H, halogen, C₁-C₁₀alkyl, -O-C_1-6alkyl, -CH(OR⁹)₂, -C-carboxy, each R² independently represents H, halogen or C₁-C₁₀alkyl, each R⁵ and R⁶ independently represents H or, alternatively, R⁵ and R⁶, attached to the same carbon atom, together with the atom to which they are attached, form C₃-C₁₀cycloalkyl, R⁹ is C₁-C₁₀alkyl. In Formula II R³ is selected from a group consisting of -CH(OR⁹)₂, C₁-C₁₀alkyl and C₃-C₁₀cycloalkyl, each R⁷ and R⁸ independently represents H, R⁹ represents C₁-C₁₀alkyl.

EFFECT: development of new compounds for increasing the efficiency of drug delivery or solving new tasks based on new technologies, in particular, aimed at the liver of compounds, which can reach the liver more effectively and are not active outside the liver, and such reduce the pharmacological or toxicological effects of the agent outside the target tissue.

26 cl, 1 tbl, 29 ex