COMPOSITIONS CONTAINING DEUTERATED DOMPERIDONE Russian patent published in 2023 - IPC A61K31/454 A61K47/14 A61K47/10 A61P1/04 A61P1/08 

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to pharmaceutical compositions containing d₄-domperidone formula (I)

(I)

or a pharmaceutically acceptable salt thereof. The formulations also contain (i) glyceryl stearate and medium chain triglyceride; or (ii) a stearoyl polyoxyl glyceride, a nonionic polymer polyethylene oxide, and a medium chain triglyceride; or (iii) non-ionic polymer polyethylene oxide and polyethylene glycol. The invention also relates to methods for treating a disorder that is gastroparesis, vomiting independent of gastroparesis, nausea associated with gastroparesis, vomiting associated with gastroparesis, gastroesophageal reflux disease, insufficient lactation, or a combination thereof, including administering to the patient the composition described herein. In some aspects, the disorder is gastroparesis. In other aspects, the disorder is a gastrointestinal reflux disease. In the following aspects, the disorder is insufficient lactation.

EFFECT: obtaining pharmaceutical compositions containing d₄-domperidone.

34 cl, 5 ex, 16 tbl, 12 dwg