NEW COMPOSITIONS AND METHODS Russian patent published in 2022 - IPC A61K31/4985 A61P25/00 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to the field of pharmaceutics, namely to a transmucosal pharmaceutical composition for the prevention and/or treatment of psychiatric and neurological diseases, containing therapeutically effective amount of 1-(4-fluoro-phenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrollo[1,2,3-de]chinoxaline-8-yl)-butane-1-one, or 1-(4-fluoro-phenyl)-4-((6bR,10aS)-2,2-d₂-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrollo[1,2,3-de]chinoxaline-8-yl)-butane-1-one, or 1-(4-fluoro-phenyl)-4-((6bR,10aS)-1,1,2,2-d₄-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrollo[1,2,3-de]chinoxaline-8-yl)-butane-1-one in the form of free bases or pharmaceutically acceptable salts; where the composition is a soluble tablet or wafer, sublingual tablet or wafer, soluble film, sublingual film, buccal film, oral gel or soluble sublingual or buccal gel.

EFFECT: invention provides compositions with high bioavailability and low level of formation of metabolites.

27 cl, 4 tbl, 3 ex