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(19)

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2 797 272

(13)

(51)

IPC

A01K67/27(2006-01-01)

C07K14/705(2006-01-01)

C12N15/85(2006-01-01)

(21) (22)

Application

2018120386, 2012-10-26

(24)

Start date

2012-10-26

(22)

Actual filing date

2012-10-26

(45)

Published

2023-06-01

(72)

Inventor

Makdonald LinnMerfi Endryu Dzhej.Makuirter DzhonTu NaksinVoronina VeraGyurer TsaganMigkher KarolinaStivens Shon

(73)

Holder

Regeneron Farmasyutikalz, Ink.

GENETICALLY MODIFIED MICE FOR T-CELL RECEPTOR Russian patent published in 2023 - IPC A01K67/27 C07K14/705 C12N15/85

Abstract RU 2797272 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to a method for producing a therapeutic agent for humans involving immunization of a genetically modified mouse with an antigen of interest. At the same time, the specified mouse contains the following in the endogenous TCR locus α: replacement of endogenous TCR V segment α at least one rearranged TCR V segmentα human, and replacement of the endogenous segment of TCR Jα at least one unrearranged human TCR segment Jα, and/or the following in the endogenous TCRβ locus: replacement of an endogenous TCR Vβ segment with at least one unrearranged human TCR Vβ segment, replacement of an endogenous TCR Dβ segment with at least one unrearranged human TCR Dβ segment, and replacement of an endogenous TCR Jβ segment with at least one unrearranged human TCR Jβ segment.

EFFECT: invention is effective for obtaining a therapeutic agent for humans containing a TCR variable domain.

18 cl, 19 dwg, 4 tbl, 10 ex

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RU 2 797 272 C1

Authors

Makdonald Linn

Merfi Endryu Dzhej.

Makuirter Dzhon

Tu Naksin

Voronina Vera

Gyurer Tsagan

Migkher Karolina

Stivens Shon

Dates

2023-06-01—Published

2012-10-26—Filed