FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to a genetically modified mouse containing a nucleic acid sequence encoding a human terminal deoxynucleotidyl transferase (TdT), functionally connected to a transcription control element, and a variable area of immunoglobulin, as well as its ES cell. The use of the above-mentioned mouse ES cell for obtaining a genetically modified mouse is also disclosed.
EFFECT: invention can be effectively used to induce the expression of an antibody containing a variable human domain.
35 cl, 16 dwg, 5 tbl, 10 ex
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