METHOD OF BIOHYBRID SCREENING OF LUNG CANCER, STOMACH CANCER, DIABETES MELLITUS AND PULMONARY TUBERCULOSIS BY EXHALED AIR Russian patent published in 2023 - IPC A61B5/08 A61B5/381 G01N33/497 G06F17/14 

FIELD: medicine.

SUBSTANCE: invention relates to the study and analysis of air exhaled by the subject, and can be used in the screening of socially significant diseases (lung cancer, stomach cancer, diabetes mellitus, pulmonary tuberculosis) in order to provide support for medical decision-making. Either one rat is used for screening for lung cancer, stomach cancer, diabetes mellitus and pulmonary tuberculosis, or four rats for each of these diseases separately. Air intake from the subjects in both cases is carried out in sampling bags. The flow rate of air from the sampling bags to the olfactory organ of the rat is 80–160 ml/s. A microelectrode matrix is placed on the rat's head, which is immersed into the olfactory bulb with eight microelectrodes and provides for the removal of bioelectric potentials from the olfactory analyzer of the rat. The processing of the received signals is carried out by decomposing each of the 8 channels using a wavelet transform using a biorthogonal wavelet spline of the 3rd and 1st orders. For each of the obtained five detailed decompositions of the signal, parameters such as root mean square (RMS) and modulo average (SpM) are calculated, as well as the resulting vector for each of the 8 channels. The vectors from all channels are combined into one resulting vector for a signal of 80 parameters, which is fed to the input of the processing block using the method of principal components. Processing is performed in pairs for all channels. The resulting compressed feature vector with dimension 3 is fed to the input of the trained classification model based on the support vector machine, the result of which is the following outcomes: "There is a risk of disease" and "The risk of disease is not detected". A conclusion on the presence/absence of the risk of the disease is issued.

EFFECT: increased efficiency of indicators "Accuracy", "Completeness", a complex statistical indicator "F-measure", "Sensitivity" and "Specificity" during biohybrid screening of lung cancer, stomach cancer, diabetes mellitus and pulmonary tuberculosis by exhaled air.

1 cl, 5 dwg, 4 tbl