OBTAINING A MICRO/NANOADJUVANT BASED ON RIZEDRONATE ZINC AND ITS USE AS A VACCINE ADJUVANT Russian patent published in 2023 - IPC A61K31/675 A61K33/30 A61K39/12 A61K39/25 A61K39/39 A61P31/22 A61P37/04 B82Y5/00 

FIELD: pharmaceutical technology.

SUBSTANCE: group of inventions relates to an adjuvant based on zinc risedronate micro/nanoparticles and a method for its production, as well as to agents and compositions containing the said adjuvant, and a method for their production. The proposed adjuvant based on zinc risedronate micro/nanoparticles contains zinc and risedronic acid at a ratio of molar concentrations of zinc:risedronic acid of 1–8:1. The method of obtaining an adjuvant includes: a) obtaining a soluble saline solution containing zinc ions; b) uniform mixing of the soluble salt solution of step a) with risedronic acid and sodium hydroxide or uniform mixing of the soluble salt solution of step a) with risedronic acid, sodium hydroxide and sodium phosphate solution by sequential precipitation, separate precipitation followed by mixing or co-precipitation to obtain an adjuvant risedronate zinc, where the obtained adjuvant has a ratio of molar concentrations of zinc:risedronic acid 1–8:1. Also a vaccine adjuvant, a pharmaceutical composition or an immunogenic composition that contains the above adjuvant, as well as a vaccine composition that contains an antigen and the above adjuvant are proposed. The method for obtaining a vaccine adjuvant of the above compositions or a carrier for drug delivery includes obtaining an adjuvant and its inclusion into the composition of these agents and compositions.

EFFECT: it is shown that the proposed adjuvant has a significant effect of enhancing humoral immunity.

17 cl, 5 tbl, 7 ex, 7 dwg