7-TRIAZOLYL-SUBSTITUTED HYDROXYSPYROSTANES WITH CYTOTOXIC ACTIVITY AGAINST HUMAN TUMOR CELLS Russian patent published in 2023 - IPC C07J71/00 A61K31/58 A61P35/00 

Abstract RU 2798105 C1

FIELD: medicine.

SUBSTANCE: invention relates to 7-(4-aryl-1,2,3-triazol-1-yl)spirostanes, structural formula (I). The invention relates to new chemical compounds, specifically to 7-(4-aryl-1,2,3-triazol-1-yl)hydroxyspirostanes of general formula (I).

EFFECT: obtaining new compounds of the spirostane series, which have the ability to inhibit the growth of human tumor cells at the level of the drug doxorubicin. The compounds are derived from the available plant spirostenol diosgenin. These properties allow the compounds to be used in medicine as an antiproliferative agent.

1 cl, 1 dwg, 1 tbl, 4 ex

(I)

пиридин-2-ил pyridine-2-il

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RU 2 798 105 C1

Authors

Mironov Maksim Evgenevich

Pokrovskii Mikhail Andreevich

Emaminia Fatemekh

Pokrovskii Andrei Georgievich

Shinkarenko Elizaveta Mikhailovna

Shults Elvira Eduardovna

Dates

2023-06-15Published

2023-02-20Filed