MACROCYCLIC COMPOUND AND ITS USE Russian patent published in 2023 - IPC C07D471/18 C07D491/22 C07D498/16 C07D498/22 A61K31/4748 A61K31/5386 A61K9/48 A61P1/16 A61P11/00 A61P13/12 A61P25/00 A61P3/00 A61P35/00 A61P43/00 A61P7/06 A61P9/00 

FIELD: heteroaromatic compounds.

SUBSTANCE: following is proposed: a compound represented by formula (I), where R¹ represents OH; R² and R³, which may be the same or different, represent either a hydrogen atom or a methyl group; X is C(=O); ring B is an unsubstituted benzene ring; ring A is a benzene ring which may have one methyl substituent; forming a structure; ring C represents where R^c1 and R^c4, which may be the same or different, represent a hydrogen atom, a chlorine atom or a methyl group, and each R^c2 and R^c3 represents a hydrogen atom; and L is -CH₂-CH₂-CH₂-CH₂-CH₂-*, -CH₂-CH₂-CH₂-CH₂-O-*, -CH₂-CH₂-CH₂-O-CH₂-* or -CH₂-CH₂-O-CH₂-CH₂-*, and where * denotes the point of attachment to ring C. Also specific compounds, a medicament and a pharmaceutical composition, methods of activating NRF2 and preventing or treating diseases associated with oxidative stress; and the use of the compound are disclosed.

EFFECT: obtaining compounds that have an activating effect on NRF2.

12 cl, 5 tbl, 68 ex