FIELD: biotechnology.
SUBSTANCE: invention relates to a system containing the following: nRNA containing a targeting domain complementary to the target sequence from the transforming growth factor receptor II geneβ (TGFBR2), and RNA-directed nuclease, as well as to the cell containing it.
EFFECT: invention is effective for mediated TGF-β inhibition of T cells in the context of tumor therapy.
21 cl, 24 dwg, 9 tbl, 6 ex
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