FIELD: biotechnology.
SUBSTANCE: group of inventions relates in particular, to antibodies and their fragments capable of binding alpha-synuclein in the form of a monomer and in fibrils, preventing alpha-synuclein aggregation induced by alpha-synuclein fibrils and a method for their production. Also presented are the following: an isolated polynucleotide encoding an antibody or its antigen-binding fragment, a cloning vector and an expression vector, a host cell for producing an antibody, and a method for treating Parkinson's disease (PD) in a patient, which includes administering to the said patient a therapeutically effective amount of the antibody or its antigen-binding fragment.
EFFECT: invention is used for the treatment of alpha-synucleinopathies, including Parkinson's disease.
23 cl, 11 tbl, 14 dwg, 10 ex
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