FIELD: immunology; pharmaceuticals.
SUBSTANCE: group of inventions relates to a vaccine containing an immunogenic glycan compound aimed at treating an infection caused by C. perfringens. A vaccine containing an immunogenic glycan compound with the structure of repeating units of poly-β-1,4-ManNAc modified with at least one 6-linked phosphoglycerol, an attenuated C. perfringens cell carrying the said glycan or bacterium engineered to express the said glycan, and a pharmaceutically acceptable diluent, carrier, and excipient or adjuvant are disclosed. Also a method of treating or preventing an infection caused by C. perfringens by administering the above vaccine is disclosed.
EFFECT: group of inventions provides an effective cross-reactive immune response that recognizes a wide range of C. perfringens strains.
11 cl, 13 dwg, 5 tbl, 8 ex
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