TREATMENT OF RESPIRATORY DISORDERS USING ARACHIDONATE 15-LIPOXYGENASE (ALOX15) INHIBITORS Russian patent published in 2023 - IPC A61K48/00 A61P11/00 

FIELD: biotechnology.

SUBSTANCE: invention relates specifically to new methods of treating patients suffering from a respiratory disorder selected from nasal polyp, allergic rhinitis, asthma, or aspirin-induced respiratory disease (AIRD). The invention involves the identification in a patient of a variant nucleic acid with a predictable loss of function of the enzyme arachidonate 15-lipoxygenase (ALOX15) encoding a human ALOX15 polypeptide, where the ALOX15 polypeptide is a variant of Thr560Met, Tyr139Cys, Leu651fs, Pro565Leu, Asn658Lys, Gly283Arg, Val474Ala, Gly 422Arg or Leu106fs, and providing the patient with an ALOX15 inhibitor or other therapeutic agent capable of treating the said diseases in the event that a detectable nucleic acid is not detected in a biological sample obtained from the patient.

EFFECT: obtaining new methods of treating patients suffering from a respiratory disorder selected from nasal polyp, allergic rhinitis, asthma, or aspirin-induced respiratory disease (AIRD).

92 cl, 1 ex, 1 tbl, 8 dwg