FIELD: medicine.
SUBSTANCE: invention relates to new chemical compounds, namely to pinane C,N-palladacycles containing L-amino acid as chelating coligand: proline, or tyrosine, or serine, or isoleucine, obtained as individual diastereomers 2a-d.
EFFECT: expanding the arsenal and obtaining new multimodal palladacycles that can be used as agents with antitumor activity, in particular against strains of neuroblastoma (SH-SY5Y), pulmonary adenocarcinoma (A549), epidermoid carcinoma of the larynx (Hep-2) and cervical carcinomas (HeLa).
3 cl, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| CHIRAL ZINC COMPLEXES WITH ETHYLENEDIAMINE TERPENE DERIVATIVES | 2022 |
|
RU2785281C1 |
| NEW STERICALLY HINDERED PHENOLS CONTAINING BENZOFUROXAN FRAGMENTS WITH ANTITUMOR ACTIVITY | 2022 |
|
RU2796810C1 |
| BROMINE-CONTAINING STERICALLY HINDERED PHENOLS WITH ANTICANCER ACTIVITY | 2023 |
|
RU2822270C1 |
| METHOD FOR OBTAINING (3BR*,7AR*,10BR*,14AR*-CIS-14C,14D)-2,9-BIS(PYRIDIN-3-YLMETHYL)OCTADECAHYDRO-1H,8H-2,3A,7B,9,10A, 14B-HEXAAZADIBENZO[FG,OP]TETRACENE AND ITS USE AS AN AGENT WITH CYTOTOXIC ACTIVITY | 2022 |
|
RU2792567C1 |
| USE OF MANNICH BASES BASED ON FUSIDIC ACID AS COMPOUNDS WITH ANTI-TUMOUR ACTIVITY | 2023 |
|
RU2819293C1 |
| ANTITUMOR AGENTS BASED ON MACRO- AND MICROELEMENT-CONTAINING POLYGALACTURONATES (OPTIONS) | 2022 |
|
RU2792613C1 |
| 4-{BIS[(HEPTYLTHIO)METHYL]AMINO}BENZAMIDE AND METHOD FOR ITS PRODUCTION | 2022 |
|
RU2796755C1 |
| 4-[(PURIN-6-YL)AMINOPOLYMETHYLENECARBONYL]-DERIVATIVES OF 3,4-DIHYDRO-3-METHYL-7,8-DIFLUORO-2H-[1,4]BENZOXAZINE WITH ANTITUMOR ACTIVITY | 2021 |
|
RU2760305C1 |
| ARILMETHYLENE BISPIRAN-2-ONE-BASED COMPLEX COMPOUNDS OF COPPER(II) EXHIBITING CYTOTOXIC ACTIVITY TO HELA CELL LINE | 2020 |
|
RU2753853C1 |
| SODIUM COBALT POLYGALACTURONATE WITH ANTITUMOR ACTIVITY | 2023 |
|
RU2794885C1 |
