ARILMETHYLENE BISPIRAN-2-ONE-BASED COMPLEX COMPOUNDS OF COPPER(II) EXHIBITING CYTOTOXIC ACTIVITY TO HELA CELL LINE Russian patent published in 2021 - IPC C07F1/08 C07D407/10 A61K31/555 A61P35/00 

Abstract RU 2753853 C1

FIELD: chemistry.

SUBSTANCE: invention relates to new biologically active compounds, namely to arylmethylene bispiran-2-one-based complex compounds of copper (II), of the formula

,

wherein at n = 4, R = H (1) or R = 3-NO2 (2) or at n = 3, R = 4-OCH3 (3).

EFFECT: proposed complex compounds exhibit a cytotoxic effect, particularly, the ability to suppress metabolic activity of the human cervical carcinoma (HeLa) cell line, and are potentially applicable in medical practice for treatment of cancerous diseases.

1 cl, 3 dwg, 1 tbl, 4 ex

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RU 2 753 853 C1

Authors

Arziamova Ekaterina Mikhailovna

Fedotova Olga Vasilevna

Burygin Gennadii Leonidovich

Dates

2021-08-24Published

2020-03-16Filed