FIELD: biotechnology.
SUBSTANCE: invention concerns a new strain of foot-and-mouth disease virus Aphtae epizooticae genotype SAT-1/I, Picornaviridae family, Aphthovirus genus, deposited in the All-Russian State Collection of Exotic Types of Foot-and-Mouth Disease Virus and Other Animal Pathogens (GKSM) FGBI "ARRIAH" under registration number No.411 - dep/22-45 — GKShM FGBI "ARRIAH", "SAT-1/Tanzania/2012" strain SAT-1/I genotype of foot-and-mouth disease virus. The presented strain is reproduced in transplanted cell cultures of Siberian mountain ibex kidney (PSGK-30), pig kidney (IB-RS-2), newborn Syrian hamster kidney (VNK-21). In a continuous suspension culture of Syrian hamster kidney cells VNK-21/SUSP/ARRIAN for 13.0-14.5 hours of incubation, the concentration of the 146S component of SAT-1/Tanzania/2012 strain of SAT-1/I genotype of the foot and mouth disease virus has an average value of 1.34±0.07 μg/cm3 (64.88±0.66%), retaining the original characteristics when passaged in cell culture VNK-21/SUSP/ARRIAH.
EFFECT: presented strain can be used for the manufacture of biopreparations for the diagnostics and specific prevention of FMD of SAT-1/I genotype and to control the antigenic activity of FMD vaccines.
1 cl, 1 dwg, 4 tbl, 5 ex
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