FIELD: biotechnology.
SUBSTANCE: invention concerns a new strain of foot-and-mouth disease virus Aphtae epizooticae genotype SAT-2/IV, Picornaviridae family, Aphthovirus genus, deposited in the All-Russian State Collection of Exotic Types of Foot-and-Mouth Disease Virus and Other Animal Pathogens (GKSM) FSBI ARRIAH under registration number No.452 - dep/23-2 — GKShM FSBI ARRIAH, SAT-2/Kenya/19/2017 strain SAT-2/IV genotype of foot-and-mouth disease virus. The presented strain is reproduced in transplanted cell cultures of Siberian Mountain Ibex Kidney (PSGK-30), Pig Kidney (IB-RS-2), and Newborn Syrian Hamster Kidney (ВНК-21). In a transplanted suspension culture of Syrian hamster kidney cells ВНК-21/SUSP/ARRIAN for 15.25± 0.54 hours of incubation, the concentration of the 146S component of SAT-2/Kenya/19/2017 strain of SAT-2/IV genotype of the foot and mouth disease virus has an average value of 1.29±0.11 mcg/cm3 (65.38±0.70%), retaining the original characteristics when passaged in ВНК-21/SUSP/ARRIAH cell culture.
EFFECT: presented strain can be used for the manufacture of diagnostic tools and specific prevention of FMD of SAT-2/I genotype and to control the antigenic activity of FMD vaccines.
1 cl, 1 dwg, 3 tbl, 5 ex
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