OXASPIRO DERIVATIVE SUBSTITUTED AT AZABICYCLIC RING, A METHOD OF ITS PRODUCTION AND ITS MEDICAL USE Russian patent published in 2023 - IPC C07D487/04 C07D471/04 A61K31/444 A61K31/4439 A61K31/4188 A61K31/4162 A61P29/00 A61P25/04 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound represented in formula (I) or a pharmaceutically acceptable salt, diastereomer, racemate or mixture of diastereomers thereof, wherein ring A is pyridin-2-yl; (R₀)_n means that the hydrogen atoms in ring A are replaced by n R₀ groups, where n is 0; Y₁ is N; Y₂ is a bond; Y₁ is directly connected to N; Y₃ is CR₃; Y₄ is CR₄; R₃ and R₄ are independently hydrogen or halogen; W is CH₂; R_a, R_b, R_c and R_d are defined as follows: (i) each of R_a and R_b independently represents hydrogen or C_1-8alkyl; or R_a and R_b together with their associated carbon atom form a three to six membered saturated monocyclic ring; R_c is hydrogen, halogen, C_1-8alkyl, C_1-8alkoxy, or halogenated C_1-8alkyl; or R_d is hydrogen or C_1-8alkyl; or (ii) each of R_a and R_b independently represents hydrogen; or R_c is linked to R_d to form a three to six membered saturated monocyclic ring or a four to six membered saturated monoheterocyclic ring, wherein the heteroatom in the four to six membered saturated monoheterocyclic ring is O or N; and m is either 0 or 1. The invention also relates to intermediate compounds of formula (I-2b).

EFFECT: new compounds have been obtained that can be used in medicine as therapeutic agents for the treatment and prevention of pain and diseases associated with pain.

14 cl, 2 tbl, 23 ex