SUBSTITUTED PYRAZOLE[1,5-a]PYRIMIDINE-7-AMINE DERIVATIVE, COMPOSITION AND PHARMACEUTICAL USE THEREOF Russian patent published in 2024 - IPC C07D487/04 A61K31/519 A61P35/00 

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical technology, namely to a pyrazolo [1,5-a]pyrimidine-7-amine derivative of formula (III-a) or (III-b), its pharmaceutically acceptable salt or its stereoisomer, where R_1a is hydrogen, C_1-6 alkyl or deuterated C_1-6 alkyl; n is 1, 2, 3 or 4; t is equal to 1, 2 or 3; each of R₁₁ and R₁₂ independently represent hydrogen; R₂ is hydrogen, C_1-6 alkyl or halogen; R₃ is hydrogen, C_1-6 alkyl, C_3-6 cycloalkyl, C_1-6 alkoxy or halogen, where C_1-6 alkyl is unsubstituted or substituted with 1, 2 or 3 substitutes selected from C_1-3 alkoxy; R₄ is hydrogen, -C(O)(C_1-3 alkyl), -(C=N)-C_1-3 alkyl or -(C=N)-NR_a0R_b0; R₅ is hydrogen; R_a is hydrogen, C_1-6 alkyl, C_3-6 cycloalkyl, cyano or halogen, where C_1-6 alkyl is unsubstituted or substituted with 1, 2 or 3 substitutes selected from halogen; R_b is hydrogen; (R₀)_m means that hydrogen atoms in the ring are substituted with m groups R₀, where m is 0; each of R_a0 and R_b0 independently represents hydrogen. Invention also relates to use of a compound of formula (III-a) or (III-b), or a pharmaceutically acceptable salt thereof, or a stereoisomer in preparing a drug for treating or preventing a disease associated with CDK9 activity.

EFFECT: obtaining compounds having inhibitory activity on CDK9 for treating CDK9-mediated diseases.

15 cl, 5 tbl, 96 ex