FIELD: biotechnology.
SUBSTANCE: methods of treating a disorder responsive to treatment with serotype E botulinum neurotoxin (BoNT/E), as well as cosmetic methods of suppressing wrinkles in the upper face, where the methods include administering BoNT/E to a human subject at a dose of 0.04 to 4 ng, where BoNT/E is a recombinant BoNT/E that does not contain complexing proteins are presented.
EFFECT: inventions allow to achieve maximum inhibition of neurotransmitter secretion from target cell or target tissue within ≤13 days after BoNT/E administration and reduce inhibition of neurotransmitter secretion from target cell or target tissue to >25% on day 14 after BoNT/E administration, leading to an effective treatment of the disorder responsive to serotype E botulinum neurotoxin.
31 cl, 14 dwg, 4 tbl, 6 ex
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