GENETICALLY ENGINEERED CELLS SENSITIVE TO CLOSTRIDIAL NEUROTOXINS Russian patent published in 2024 - IPC C12N5/79 C12N5/09 G01N33/50 

Abstract RU 2824389 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to a cell containing an exogenous nucleic acid, which provides expression or overexpression of a clostridial neurotoxin receptor or a variant thereof, or a fragment thereof, which has the ability to bind clostridial neurotoxin, an exogenous nucleic acid which provides expression or overexpression of a ganglioside having a clostridial neurotoxin binding affinity, and an exogenous nucleic acid which provides expression or overexpression of an indicator protein cleaved by a clostridial neurotoxin, as well as a method for production thereof.

EFFECT: invention is effective for identifying the composition of Clostridial neurotoxin for therapeutic and cosmetic use, for characterizing the activity of the composition of Clostridial neurotoxin, as well as for analysis for determining activity of modified or recombinant neurotoxin.

42 cl, 13 dwg, 12 ex

Similar patents RU2824389C2

Title Year Author Number
CELLS HIGHLY SENSITIVE TO CLOSTRIDIAL NEUROTOXIN 2020
  • Ojler, Dzhordzh E.
  • Gertts, Barri
RU2831112C2
TREATMENT OF SKIN DISEASES 2021
  • Maignel, Jacquie
  • Krupp, Johannes
RU2840027C1
NON-TOXIC POLYPEPTIDES OF CLOSTRIDIAL NEUROTOXIN FOR USE IN TREATING NEUROLOGICAL DISORDERS 2020
  • Fonfria Subiros, Elena
  • Lewandowska, Agnieszka
RU2839368C1
THERAPEUTIC AND COSMETIC USE OF SEROTYPE E NEUROTOXIN BOTULINUM 2019
  • Pons, Laurent
RU2800604C2
MODIFIED BOTULINUM NEUROTOXIN FOR TREATING EXTREMITY SPASTICITY 2021
  • Grigore, Nicolae
  • Ruffle, Katie
  • Picaut, Philippe
RU2841585C1
HYBRID NEUROTOXINS 2017
  • Fonfria Subiros, Elena
  • Burgin, David
RU2782382C2
METHODS FOR PRODUCING PROTEOLYTICALLY PROCESSED POLYPEPTIDES 2018
  • Rummel, Andreas
RU2719164C1
METHODS FOR PRODUCING PROTEOLYTICALLY PROCESSED POLYPEPTIDES 2019
  • Rummel, Andreas
RU2727402C1
ENGINEERED BOTULINUM NEUROTOXIN 2016
  • Dong Min
  • Peng Lisheng
  • Tao Liang
RU2746736C2
CONSTRUCTED BOTULINUM NEUROTOXIN 2017
  • Dong, Min
  • Tao, Liang
RU2789302C2

RU 2 824 389 C2

Authors

Ojler, Dzhordzh E.

Gertts, Barri

Dates

2024-08-07Published

2020-06-08Filed