NON-TOXIC POLYPEPTIDES OF CLOSTRIDIAL NEUROTOXIN FOR USE IN TREATING NEUROLOGICAL DISORDERS Russian patent published in 2025 - IPC A61K38/48 C07K14/33 A61P25/00 A61P25/02 A61P25/28 

Abstract RU 2839368 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to the use of a polypeptide in stimulating the growth or recovery of neurons for treating a neurological disorder in a subject, where the polypeptide contains: a light chain of clostridial neurotoxin (L-chain), where the L-chain is catalytically inactive and/or a fragment of a heavy chain of clostridial neurotoxin (H-chain), and wherein the polypeptide does not contain either the HN domain of the clostridial neurotoxin, nor the HC domain of the clostridial neurotoxin.

EFFECT: disclosed are non-toxic polypeptides of Clostridial neurotoxin for use in treating neurological disorders.

18 cl, 10 dwg, 5 ex

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RU 2 839 368 C1

Authors

Fonfria Subiros, Elena

Lewandowska, Agnieszka

Dates

2025-04-30Published

2020-09-30Filed