1,3-DIOXO-N,N'-DIPHENYLISOINDOLINE-2-CARBOXIMIDAMIDE, METHOD OF ITS PREPARATION AND ANALGESIC AGENT Russian patent published in 2023 - IPC C07D209/48 A61K31/4035 A61P29/00 

Abstract RU 2800863 C1

FIELD: organic and medicinal chemistry.

SUBSTANCE: invention relates to 1,3-dioxo-N,N'-diphenylisoindoline-2-carboximidamide of formula I. The invention also relates to a method of producing a compound of formula I and an analgesic agent based on it. The method of obtaining 1,3-dioxo-N,N'-diphenylisoindoline-2-carboximidamide of formula I is performed by boiling a mixture of diphenylguanidine and phthalic anhydride at a molar ratio of 1:1.2, respectively, in toluene for 2 hours, with solvent distilled off, and the residue of the target product recrystallized from acetone.

EFFECT: 1,3-dioxo-N,N'-diphenylisoindoline-2-carboximidamide compound with analgesic activity.

3 cl, 2 dwg, 3 tbl, 3 ex

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RU 2 800 863 C1

Authors

Trukhanova Yuliya Aleksandrovna

Yakovlev Igor Pavlovich

Chernov Nikita Maksimovich

Yuskovets Valerij Nikolaevich

Kuvaeva Elena Vladimirovna

Sopova Marina Vasilevna

Semakova Tamara Leonidovna

Ksenofontova Galina Vladimirovna

Dates

2023-07-31Published

2022-05-30Filed