FIELD: pharmaceutical chemistry; pharmacology.
SUBSTANCE: invention concerns new 5-amino-substituted thietane-containing 3-bromo-4-nitropyrazoles, namely, compounds I-IX, in which, when n = 0, then NRR' is anilino (compound I) or diethanolamino (compound II); or, when n = 2, then NRR' is cyclohexylamino (compound III), benzylamino (compound IV), pyrrolidino (compound V), piperidino (compound VI), piperazino (compound VII), 4-methylpiperazino-1 (compound VIII) or aniline (compound IX).
EFFECT: compounds of the invention have antidepressant activity comparable to that of amitriptyline.
11 cl, 1 tbl, 11 ex
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