FIELD: chemistry; pharmaceutics.
SUBSTANCE: invention relates to pharmaceutical chemistry and pharmacology, specifically to 5-amino-substituted 3-bromo-4-nitro-1H-pyrazole derivative of general formula given below, in which NRR' is benzylamino (compound I), anilino (compound II), pyrrolidino-1 (compound III), piperidino-1 (compound IV) and 4-methylpiperazino-1 (compound V).
EFFECT: disclosed compounds have antidepressant activity comparable to amitriptyline.
7 cl, 1 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 5-AMINE-SUBSTITUTED THIETHANE-CONTAINING 3-BROMO-4-NITROPYRAZOLES WITH ANTIDEPRESSANT ACTIVITY | 2022 |
|
RU2801039C1 |
| 5-AMINO-SUBSTITUTED 3-BROMO-4-NITRO-1-(THIETAN-3-YL)-1H-PYRAZOLES EXHIBITING ANTIDEPRESSANT ACTIVITY | 2023 |
|
RU2817972C1 |
| N-MONO- AND N,N-DITHIETANE-CONTAINING 5-BROMO-2,4-DIHYDRO-1,2,4-TRIAZOL-3-ONES, EXHIBITING ANTIDEPRESSANT ACTIVITY | 2024 |
|
RU2826999C1 |
| 1-(1,1-DIOXOTIETHAN-3-yl)-4-(2-OXO-2-PHENYLETHIL)-1,2,4-TRIAZOL-4-th BROMIDE, SHOWING ANTIDEPRESSIVE ACTIVITY | 2022 |
|
RU2785340C1 |
| 5-BROMO-2-(THIETAN-3-YL)-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE DERIVATIVES, EXHIBITING ANTIDEPRESSANT ACTIVITY | 2011 |
|
RU2459818C1 |
| METHOD OF OBTAINING 5-AMINOSUBSTITUTED 1-(1-ADAMANTYL)-3,4-DINITRO-1H-PYRAZOLES | 2013 |
|
RU2533557C1 |
| 2-BROMO-1-(THIETANYL-3)IMIDAZOLE-4,5-DICARBOXYLIC ACID DERIVATIVES EXHIBITING ANTIDEPRESSANT ACTIVITY | 2014 |
|
RU2537948C1 |
| DERIVATIVES OF 3-METHYL-7-(THETANYL-3)-XANTHINE POSSESSING HEMORHEOLOGICAL ACTIVITY | 2006 |
|
RU2316551C1 |
| 2-SUBSTITUTED-1,2,4,5-TETRAHYDRO-3H-PYRROLO[1,2-a][1,4]DIAZEPIN-3-ONES | 2011 |
|
RU2472795C1 |
| TRIPEPTIDE HAVING NEUROPSYCHOTROPIC ACTIVITY | 2023 |
|
RU2823022C1 |
