FIELD: organic chemistry; pharmaceuticals.
SUBSTANCE: group of inventions is directed to the treatment of diseases and disorders associated with elevated levels of CX3CR1 and/or CX3CL1. Compound of formula I, where the values of the radicals R1, R2, Q1 are as defined in paragraph 1 of the claims is disclosed. Also the following is disclosed: a pharmaceutical composition based on a compound of formula (I) having fractalkine receptor antagonist activity, a method of treating or preventing a disease or disorder associated with elevated levels of CXCR1 and/or CX3CL1, and the use of the above compounds for the manufacture of a medicinal product. Also a method of preparing compounds represented by the general formula (I) is disclosed.
EFFECT: group of inventions provides an effective antagonistic effect of the fractalkine receptor with high stability and bioavailability.
36 cl, 8 tbl, 7 ex
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