NEW DERIVATIVES OF 5-SUBSTITUTED 7-AMINO-[1, 3] THIAZOLO [4, 5-d]PYRIMIDINE Russian patent published in 2011 - IPC C07D513/04 A61K31/519 A61P9/10 A61P25/00 A61P11/06 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a derivative of 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine of formula

and its optical isomers and pharmaceutically acceptable salts where R¹ represents CH₃ or CH₃CH₂; R² represents H, 2-F, 2-Cl, 3-F, 3-OCN₃, 3-CN, 3-CF₃, 3-CONH₂ or 3-SO₂CH₃; R³ represents H or CH₃; R⁴ represents H or CH₃; and R⁵ represents H; or when R⁴ represents CH₃, R⁵ represents H or F. Also, the invention refers to methods for producing the compounds of formula (I) and to pharmaceutical compositions exhibiting CX₃CR1 receptor antagonist properties containing the compounds of formula (I).

EFFECT: production of 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine as selective CX₃CR1 receptor antagonists.

15 cl, 2 tbl, 18 ex