HEMAGLUTININ MUTANTS OF THE INFLUENZA VIRUS Russian patent published in 2023 - IPC C07K14/11 A61K39/145 C12N15/44 C07K16/10 C12N15/82 

FIELD: biotechnology.

SUBSTANCE: following is described: a modified influenza H3 hemagglutinin (HA) protein for producing a virus-like particle (VLP), wherein the HA protein contains an amino acid sequence containing at least one substitution compared to the corresponding wild-type amino acid sequence, wherein at least one substitution is a substitution of one or more than one amino acid corresponding to amino acids at position 382, 384, 392, or 431 of the reference sequence of SEQ ID NO: 92. Also a nucleic acid for producing a modified influenza H3 HA protein, wherein the nucleic acid contains a nucleotide sequence encoding the modified influenza H3 HA protein is described. Also the following is provided: a virus-like particle (VLP) for inducing an immune response to influenza infection in a subject, the VLP comprising a modified influenza H3 hemagglutinin (HA) protein and a method of producing such a VLP in a plant, a plant part, or a plant cell. Such a plant or a part of a plant or a plant cell is represented. The use of VLP to induce immunity to influenza infection in a subject is described, including in the form of a composition. Also a method of increasing the production yield of influenza virus-like particles (VLPs) in a plant, a plant part, or a plant cell is provided.

EFFECT: invention expands the arsenal of agents to prevent influenza.

17 cl, 9 dwg, 7 tbl, 4 ex