FIELD: medicine; pharmacy; chemistry.
SUBSTANCE: method of determining epimers of budesonide in substances or dosage forms is disclosed, in which budesonide, which is a racemate of 22R and 22S, is dissolved in deuterated dimethyl sulfoxide (DMSO-d6) or deuterated chloroform solvent (CDCl3), 1H or 13C nuclear- magnetic resonance spectroscopy is identified and quantified.
EFFECT: invention provides selective determination of the epimer composition of budesonide and reduction of total labor costs at the stages of sample preparation and analysis.
9 cl, 14 dwg, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR DETERMINING IMPURITY A IN DOSAGE FORMS OF GABAPENTIN | 2021 |
|
RU2773851C1 |
| METHOD FOR SIMULTANEOUS DETERMINATION OF DEGREES OF OXIDATION AND ALKYLATION OF AZOXIMER BROMIDE - ACTIVE SUBSTANCE OF POLYOXIDONIUM - BY METHOD C NMR SPECTROSCOPY | 2019 |
|
RU2713805C1 |
| METHOD FOR IDENTIFICATION AND QUANTITATIVE DETERMINATION OF OLIGOPEPTIDES IN A PHARMACEUTICAL SUBSTANCE "PEPTOFORCE" BY NMR SPECTROSCOPY | 2019 |
|
RU2709020C1 |
| ANTIBACTERIAL AGENTS BASED ON QUATERNARY AMMONIUM SALTS | 2014 |
|
RU2561281C1 |
| AZA-CROWN-CONTAINING N-ARYL-1,8-NAPHTHALIMIDES AND METHODS FOR PRODUCTION THEREOF | 2017 |
|
RU2656106C1 |
| QUATERNARY AMMONIUM SALTS BASED ON DERIVATIVES OF VITAMIN B6 | 2015 |
|
RU2607522C1 |
| METHOD OF OBTAINING OREGANOL A, HAVING NEPHROTROPIC AND NEUROTROPIC ACTIVITY | 2022 |
|
RU2804299C1 |
| 3-TRIAZENONE INDOLES POSSESSING MYCOBACTERIUM ACTIVITY | 2016 |
|
RU2724334C1 |
| 4-SUBSTITUTED N-ARYL-1,8-NAPHTHALIMIDES, EXHIBITING PROPERTIES OF FLUORESCENT SENSORS ON METAL CATIONS AND METHODS FOR PRODUCTION THEREOF | 2012 |
|
RU2515195C1 |
| METHOD OF PRODUCING 5-SUBSTITUTED 1,2,4-TRIAZOLE-3-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF FROM UNIVERSAL PRECURSOR | 2015 |
|
RU2605414C1 |
