METHOD OF OBTAINING OREGANOL A, HAVING NEPHROTROPIC AND NEUROTROPIC ACTIVITY Russian patent published in 2023 - IPC A61K36/53 B01D11/02 B01D15/08 A61P13/00 A61P25/00 

FIELD: chemical; pharmaceutical industry.

SUBSTANCE: invention relates to a method of producing oreganol A, which has nephrotropic and neurotropic activity. A method of producing oreganol A, which has nephrotropic and neurotropic activity, with the preliminary production of aqueous-alcoholic extract from medicinal plant raw materials using the sorbent chromatography method, according to which the extract is obtained from the oregano herb by ordinary extraction with 70% ethyl alcohol in the raw material-extractant ratio of 1:5, extraction is carried out by fractional maceration until the raw material is completely depleted, the resulting combined aqueous-alcoholic extract is evaporated to a thick extract, which is then mixed with silica gel L 40/100, dried and applied to a column filled with silica gel in the form of a suspension in chloroform, the target substance is eluted a mixture of chloroform:ethyl alcohol 96% in a ratio of 70:30 using column chromatography on silica gel, further purification is carried out by reprecipitation in a mixture of acetone and chloroform with a yield of 1.05% and a degree of purity of 99.5%.

EFFECT: above method allows to obtain oreganol A, which has nephrotropic and neurotropic activity with a substance yield of 1.05% and a purity of 99.5%.

1 cl, 4 dwg, 1 ex