INTEGRATED HUMAN PLATELET LYSATE, A METHOD OF PRODUCING INTEGRATED HUMAN PLATELET LYSATE AND THE USE OF INTEGRATED HUMAN PLATELET LYSATE FOR THE TREATMENT OF NEUROLOGICAL DISORDERS Russian patent published in 2023 - IPC A61K35/19 A61P25/28 

FIELD: medicine.

SUBSTANCE: group of inventions relates to a method of obtaining heat-treated pooled human platelet lysate, heat-treated pooled human platelet lysate, as well as the use of heat-treated pooled human platelet lysate for the treatment of amyotrophic lateral sclerosis. A process for preparing a heat-treated pooled human platelet lysate comprises the following steps of: (a) providing pooled human platelet lysate (pHPL), (b) heat treating pooled human platelet lysate at a temperature of 56°C for 30 minutes, (c) purification by centrifugation at 4°C for 15 minutes at 10,000g, which includes, after step (b), a virus inactivation or virus removal step performed by solvent-detergent treatment (S/D treatment), detergent-only treatment, pasteurization, steaming, low pH treatment, caprylic acid treatment and nanofiltration. The following is proposed: a heat-treated pooled human platelet lysate obtained by the above method of enhancing the treatment of amyotrophic lateral sclerosis (ALS) by inducing an improved neuroprotective effect as well as repairing nerve cells, having a fibrinogen content of less than 5 wt.% of the fibrinogen content in untreated pHPL, and having a content of fibrinogen less than 50 ng/ml. The use of a heat-treated pooled human platelet lysate as defined above or prepared as described above for the treatment of amyotrophic lateral sclerosis (ALS) is also proposed.

EFFECT: above group of inventions makes it possible to obtain a combined human platelet lysate capable of enhancing the treatment of neurological disorders by inducing an improved neuroprotective effect, as well as restoring nerve cells.

11 cl, 6 dwg, 1 tbl, 2 ex