FIELD: biotechnology.
SUBSTANCE: described is an expression vector based on human adenovirus serotype 5 inducing cross-protective immunity to influenza A subtype H3 viruses. What is also described is a pharmaceutical composition for protection against influenza A subtype H3 viruses containing said expression vector in an effective amount. Also described is the use of the pharmaceutical composition for protecting a subject from influenza A subtype H3 viruses and in the composition of an influenza vector vaccine.
EFFECT: technical result consists in obtaining an expression vector based on human adenovirus serotype 5 with deletion of E1 and E3 regions, carrying a modified hemagglutinin gene of influenza A virus of antigenically distant subtype H3, capable of providing induction of cross-protective immunity against infection caused by influenza A subtype H3 viruses pathogenic for humans, without antigen imprinting effect when administered to a subject as part of a pharmaceutical composition or an influenza vaccine.
7 cl, 5 dwg, 2 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| EXPRESSION VECTOR BASED ON HUMAN ADENOVIRUS 5 SEROTYPE, INDUCING CROSS-PROTECTIVE IMMUNITY TO INFLUENZA A VIRUSES OF SUBTYPE H1, AND A PHARMACEUTICAL COMPOSITION BASED ON IT | 2023 |
|
RU2802753C1 |
| VACCINE AGAINST INFLUENZA TYPE A, INFLUENZA TYPE B AND COVID-19 | 2021 |
|
RU2751485C1 |
| STRAIN OF A RECOMBINANT PSEUDO ADENOVIRAL PARTICLE BASED ON HUMAN ADENOVIRUS GENOME OF SEROTYPE 5 Ad5-tetOFF-E3-HA125 SEROTYPE, CARRYING HAEMAGGLUTININ CONSENSUS GENE OF INFLUENZA VIRUS SUBTYPES H1, H2, H5 FOR PRODUCING INFLUENZA IMMUNOGENIC PREPARATIONS, METHOD FOR PRODUCING GENE | 2018 |
|
RU2713722C1 |
| UNIVERSAL ANTI-INFECTIOUS VACCINE | 2015 |
|
RU2618918C2 |
| RECOMBINANT TRIVALENT INFLUENZA VACCINE | 2012 |
|
RU2485973C1 |
| BROAD-SPECTRUM M2 PROTEIN ECTODOMAIN AVIAN INFLUENZA TYPE A VACCINE | 2014 |
|
RU2571944C1 |
| RECOMBINANT PSEUDO ADENOVIRAL PARTICLE BASED ON HUMAN BEING ADENOVIRUS GENOME OF 5-TH SEROTYPE FOR INDUCTION OF SPECIFIC IMMUNITY TO INFLUENZA VIRUS A OF H3N2 SUBTYPE AND METHOD OF ITS USE | 2012 |
|
RU2507258C1 |
| RECOMBINANT PSEUDO ADENOVIRAL PARTICLE BASED ON HUMAN BEING ADENOVIRUS GENOME OF 5-TH SEROTYPE FOR INDUCTION OF SPECIFIC IMMUNITY TO INFLUENZA VIRUS A OF H1N1 SUBTYPE AND METHOD OF ITS USE AS COMPONENT FOR VACCINE PRODUCTION | 2012 |
|
RU2507257C1 |
| EXPRESSION VECTOR BASED ON HUMAN ADENOVIRUS 19 SEROTYPE AND METHOD OF ITS APPLICATION | 2023 |
|
RU2811791C1 |
| RECOMBINANT PSEUDO-ADENOVIRUS PARTICLE BASED ON GENOME OF HUMAN ADENOVIRUS OF SEROTYPE 5, PRODUCING INFLUENZA HEMAGGLUTININ OF STRAIN A/Brisbane/59/2007(H1N1) AND METHOD OF ITS USE | 2012 |
|
RU2523599C1 |
