FIELD: biotechnology.
SUBSTANCE: following is proposed: a polypeptide involved in the production of a purine nucleotide selected from the group XMP (xanthosine monophosphate) or GMP (guanosine monophosphate), in which the amino acid corresponding to position 29 in the following SEQ ID NO: 3 is replaced by another amino acid selected from glycine, alanine, valine, leucine, isoleucine, methionine, phenylalanine, tryptophan, proline, serine, threonine, cysteine, tyrosine, asparagine, glutamine, aspartic acid, glutamic acid, lysine and histidine. Also the following is proposed: a polynucleotide encoding the specified polypeptide, a microorganism for producing a purine nucleotide selected from the XMP or GMP group, containing the specified polypeptide or a polynucleotide encoding the specified polypeptide, a method for producing a purine nucleotide selected from the XMP or GMP group. Also the following is proposed: a composition for producing a purine nucleotide selected from the XMP or GMP group, and a method of increasing the ability of a microorganism to produce XMP or GMP.
EFFECT: invention makes it possible to obtain purine nucleotides with high efficiency.
8 cl, 9 tbl, 4 ex
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