EMULSION COMPOSITION FOR TOPICAL USE CONTAINING NON-STEROID ANTI-INFLAMMATORY AGENT Russian patent published in 2023 - IPC A61K9/00 A61K31/00 A61K47/14 

FIELD: pharmaceutical industry.

SUBSTANCE: group of inventions relates to a composition for the treatment of pain. Emulsion composition for the treatment of pain, selected from the group including pain in the joints, bones, ligaments, tendons and muscles contains the following: (i) from 7 to 15 wt.% of a non-steroidal anti-inflammatory drug; (ii) from 15 to 50 wt.% of isopropyl myristate; (iii) from 25 to 50.2 wt.% of water; (iv) one or more emulsifiers; (v) one or more pH adjusters; and (vi) one or more solubilizers, wherein the said emulsion composition contains 5 or less wt.% of C₁-C₄ alcohols, one or more pH adjusters include diethylamine, one or more solubilizers include propylene glycol, the said non-steroidal anti-inflammatory drug is selected from the group consisting of ibuprofen, ketoprofen, diclofenac, and the said emulsion composition has a pH in the range of 5 to 7. A method of treating pain in joints, bones, ligaments, tendons and muscles in a subject is characterized by the following: the composition according to claim 1 is applied dermally at a dosage of 2.67 g, which corresponds to 200 mg of ibuprofen, once to the said subject.

EFFECT: above composition is effective for the treatment of pain selected from the group including pain in the joints, bones, ligaments, tendons and muscles, is characterized by increased bioavailability, stability, while the composition has a lower degree of conversion of ibuprofen to ibuprofen-propylene glycol ester.

7 cl, 4 tbl, 2 ex