USE OF MITOXANTHRON LIPOSOME FOR THE TREATMENT OF NON-HODGKIN'S LYMPHOMA Russian patent published in 2023 - IPC A61K31/136 A61K9/127 A61P25/00 

FIELD: medicine; oncology.

SUBSTANCE: invention is intended for the treatment of lymphoma, which is diffuse large B-cell lymphoma or peripheral T-cell lymphoma, relapsed or refractory diffuse large B-cell lymphoma or peripheral T-cell lymphoma. A method of treating lymphoma involves administering to a subject in need thereof a liposomal pharmaceutical formulation of mitoxantrone. The mitoxantrone liposomal pharmaceutical preparation contains mitoxantrone liposomes, which have a particle size of approximately 30–80 nm and contain mitoxantrone as an active ingredient. Mitoxantrone and a polyvalent counterion in liposomes form a poorly soluble precipitate. The phospholipid bilayer of liposomes contains a phospholipid with a phase change temperature (Tm) higher than the body temperature, so that the phase change temperature of the liposomes is higher than the body temperature.

EFFECT: use of the invention provides effective treatment of the said lymphoma.

13 cl, 6 tbl, 7 ex