USE OF MITOXANTRONE HYDROCHLORIDE LIPOSOME Russian patent published in 2024 - IPC A61K31/136 A61K9/127 A61P35/00 

FIELD: pharmaceutics.

SUBSTANCE: group of inventions relates to the use of mitoxantrone hydrochloride liposome in the manufacture of a medicinal agent for the treatment of ovarian cancer, stomach cancer or squamous cell carcinoma of the head and neck, as well as to a method of treating ovarian cancer, stomach cancer or squamous cell carcinoma of the head and neck in a subject. Use of mitoxantrone hydrochloride liposome in the preparation of a medicinal agent for the treatment of ovarian cancer, gastric cancer or squamous cell carcinoma of the head and neck, where ovarian cancer is difficult to treat with platinum preparations or resistant to treatment with platinum preparations recurrent ovarian cancer, gastric cancer is advanced gastric cancer and squamous cell carcinoma of head and neck is recurrent or metastatic squamous cell carcinoma of head and neck, for which the first-line therapy proved to be ineffective. Method of treating ovarian cancer, gastric cancer or squamous cell carcinoma of the head and neck in a subject, comprising administering to the subject a pharmaceutical composition, containing a therapeutically effective amount of mitoxantrone hydrochloride liposome, where ovarian cancer is difficult to treat with platinum preparations or resistant to treatment with platinum preparations recurrent ovarian cancer, gastric cancer is advanced gastric cancer and squamous cell carcinoma of head and neck is recurrent or metastatic squamous cell carcinoma of head and neck, for which the first-line therapy proved to be ineffective.

EFFECT: group of inventions described above makes it possible to treat difficult to treat with platinum preparations or resistant to treatment with platinum preparations recurrent ovarian cancer, advanced gastric cancer and recurrent or metastatic squamous cell carcinoma of head and neck, for which the first-line therapy proved to be ineffective.

43 cl, 4 ex